Deciphering vancomycin resistance in <i>Enterococcus faecium</i>: gene distribution, sequence typing, and global phylogenetic analysis.

ABSTRACT:

Objective

This study analyzes the global prevalence and distribution of vancomycin resistance genes (van) in Enterococcus faecium and examines the genetic relationship and epidemiological characteristics of strains carrying these genes.

Method

A total of 3,256 E. faecium genome sequences were downloaded, and 2,235 high-quality genomes were retained after quality filtering. The blastn tool was used to screen these genomes for van genes, and sequence types (STs) were determined using pubMLST profiles.

Result

Among the 2,235 genomes, 1,071 (47.9%) harbored van genes, with eight genotypes identified, including vanA, vanB, vanD, and vanM, accounting for 47.6%. There were 83 distinct STs among the strains carryi

SUBMITTER: Yan R 

PROVIDER: S-EPMC12394535 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature