The U-Shaped Relationship Between Serum Bicarbonate Levels and 28-Day Mortality in Patients With Sepsis: A Retrospective Cohort Study of MIMIC-IV Database.

ABSTRACT:

Background

The elevated mortality rate associated with sepsis is a primary global health concern. The correlation between bicarbonate levels and mortality risk in sepsis remains unclear.

Method

A retrospective cohort study was conducted using data from the MIMIC-IV database, including 12 744 adult sepsis patients. The primary exposure was serum bicarbonate levels, categorized into quintiles. The primary outcome was 28-day mortality, and secondary outcomes included 90-day mortality. Multivariable Cox regression models adjusted for demographic, clinical, and laboratory variables were used to examine the relationship between bicarbonate levels and mortality. Curve fitting and sensitivity analyses were performed to validate the findings.

Results

A U-shaped relationship be

SUBMITTER: Liang M 

PROVIDER: S-EPMC12394846 | biostudies-literature | 2025 Jul-Sep

REPOSITORIES: biostudies-literature