Exploring novel thiazole-based minor groove binding agents as potential therapeutic agents against pathogenic <i>Acanthamoeba castellanii</i>.

ABSTRACT: Due to limited advances in diagnosis and targeted therapy, as well as poor understanding of pathophysiology, infections due to Acanthamoeba have remained a medical concern. With their ability to selectively bind to DNA sequences, minor groove binders have emerged as useful therapeutic agents against parasitic infections. Herein, 6 novel thiazole-based minor groove binders were synthesized. Purification of intermediate compounds was accomplished by utilising silica gel column chromatography, while thin-layer chromatography was utilised to monitor reactions. The purification of the final products was achieved using liquid chromatography. Confirmation of structures was achieved by NMR spectroscopy and mass spectrometry. All compounds were evaluated against pathogenic A. castellanii

SUBMITTER: Alniss HY 

PROVIDER: S-EPMC12394913 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature