Caspase-11 regulates systemic inflammation and cell death in a cell-specific manner after trauma with shock.

ABSTRACT: Severe trauma releases damage-associated molecular patterns (DAMPs), which activate the immune system via pattern recognition receptors. This triggers inflammatory cascades that can lead to systemic inflammatory response syndrome, immunosuppression, and multiple organ dysfunction syndrome. Pyroptosis is an inflammatory form of cell death mediated by caspase-11 and gasdermin D (GsdmD). In this study, we examined caspase-11's effects on inflammation, tissue damage, and neutrophil infiltration in a model of severe tissue injury. Male C57BL/6J (WT), caspase-11-/-, cell-specific caspase-11-/- mice (endothelial-specific caspase-11-/- [casp11EC-/-]), platelet-specific caspase-11-/- (casp11plt-/-), and hepatocyte-specific caspase-11-/- (casp11HC-/-) mice were subjected to polytrauma, consisting of

SUBMITTER: Mulla J 

PROVIDER: S-EPMC12394988 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature