Tetrazole derivatives synthesis <i>via</i> green one-pot oxidation of benzyl alcohol using Cu(ii) immobilized on nanodiamond@folic acid catalyst.

ABSTRACT: Tetrazoles are highly significant in pharmaceuticals, drug delivery, and anticancer treatments. In this work, the development of a highly effective nanocatalyst, which was synthesized by functionalizing nanodiamonds (NDs) substrate with folic acid (FA) and stabilizing Cu(ii) on the nanocomposite. The ND@FA-Cu(ii) nanocatalyst has demonstrated superior thermal stability, non-toxicity, little catalyst consumption, and reusability (up to five cycles), rendering it both cost-effective and environmentally sustainable. The catalytic efficacy of ND@FA-Cu(ii) was assessed in the production of 1H-tetrazole derivatives employing two methodologies. A one-pot synthesis using malononitrile, sodium azide, and benzyl alcohol (oxidized in acetonitrile) effectively yielded 5-substituted 1H-tetrazoles. The

SUBMITTER: Ramezani A 

PROVIDER: S-EPMC12395028 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature