Differential modulation of SARS-CoV-2 infection by complement factor H and properdin.

ABSTRACT:

Introduction

An unbalanced immune response and excessive inflammation are the major hallmarks of severe SARS-CoV-2 infection, which can result in multiorgan failure and death. The dysregulation of the complement system has been shown in various studies as a crucial factor in the immunopathology of SARS-CoV-2 infection. Complement alternative pathway has been linked to the excessive inflammation in severe SARS-CoV-2 infection in which decreased levels of factor H (FH) and elevated levels of properdin (FP) were observed. The current study investigated the potential immune protective roles of FP and FH against SARS-CoV-2 infection.

Methods

The interactions between FH and FP and the SARS-CoV-2 spike (S) and its receptor binding domain (RBD) were evaluated using direct ELISA. The

SUBMITTER: Kishore U 

PROVIDER: S-EPMC12395051 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature