Pharmacological inhibition of IL12β is effective in treating pressure overload-induced cardiac inflammation and heart failure.

ABSTRACT:

Background and objective

Emerging evidence indicates that inflammation regulates cardiac remodeling and heart failure (HF). IL12β is a subunit for proinflammatory cytokines IL12 and IL23. However, the effect of IL12β inhibition on HF development and the underlying mechanism is not understood.

Methods

We determined the effect of pharmacological inhibition of IL12β using IL12β blocking antibody on transverse aortic constriction (TAC)-induced left ventricular (LV) inflammation and HF development.

Results

IL12β blocking antibody significantly attenuated TAC-induced LV immune cell infiltration, hypertrophy, fibrosis, dysfunction, and the consequent pulmonary inflammation and remodeling. More specifically, we found that IL12β blocking antibody significantly attenuated TAC-i

SUBMITTER: Bhattarai U 

PROVIDER: S-EPMC12395052 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature