Retinal Structures in Autism Spectrum Disorder: Results from a Case-Control Study.

ABSTRACT:

Objective

To assess retinal structures in patients with autism spectrum disorder (ASD) and its correlation with cognitive impairments and brain volumes.

Design

A retrospective case-control study.

Subjects

Adults with ASD and matched neurotypical controls were identified from the UK Biobank (UKBB). The exclusion criteria included a history of neurodegenerative diseases, optic nerve pathology, retinal disorders, glaucoma surgery, high refractive error, or intraocular pressure outside the range of 6 to 21 mmHg.

Methods

Using OCT images, 9 distinct retinal layers were segmented: the retinal nerve fiber layer (RNFL), ganglion cell layer, inner plexiform layer, inner nuclear layer (INL), combined outer plexiform layer and outer nuclear layer, photoreceptor inner segm

SUBMITTER: Montazeri F 

PROVIDER: S-EPMC12395168 | biostudies-literature | 2025 Nov-Dec

REPOSITORIES: biostudies-literature