Cancer-associated mesenchymal stem cell exosomes facilitate non-small cell lung cancer cell viability and invasiveness by delivering miR-182 in a FBXW7-related AKT and ERK-dependent pathway.

ABSTRACT: Cancer-associated mesenchymal stem cells (CA-MSCs) modulate the tumor microenvironment and promote tumor progression. The present study aimed to investigate the effects of CA-MSCs, CA-MSC-derived exosomes and CA-MSC exosome-derived microRNA (miR)-182 on non-small cell lung cancer (NSCLC) cell viability and invasiveness. CA-MSCs were established by treating MSCs with supernatant from NSCLC cells. Then, two NSCLC cell lines (A549 and H1299) were treated with CA-MSCs, CA-MSCs + GW4869 (inhibits exosomes) and CA-MSC exosomes. Additionally, miR-182 inhibitor was added to CA-MSCs and the related exosomes were used to treat NSCLC cells. Furthermore, miR-182 mimic and F-box and WD repeat domain containing 7 (FBXW7) overexpression vector were used to treat NSCLC cells. The results indicated that CA

SUBMITTER: Sun Y 

PROVIDER: S-EPMC12395218 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature