Self-assembled block copolymer domains as macromolecular ion transport systems in biological membranes.

ABSTRACT: Synthetic ion channels represent an emerging class of therapeutics. However, most synthetic ion channels are derived from small molecules, whose rapid clearance from the body limits their therapeutic potential. Here, we report macromolecular ion transport systems based on amphiphilic polyether block copolymers. The block copolymers self-assemble into vesicles that are spontaneously incorporated into biological membranes to form polymer-rich domains. The hydrophobic core of the domains, which features ether-oxygen atoms and the presence of water molecules, is analogous to the permeation pathways of natural ion channels such as KcsA. In addition, the inherent thermoresponsive properties of these polymer domains enable on/off switching of ion transport in response to temperature variations, a

SUBMITTER: Kosaka S 

PROVIDER: S-EPMC12395278 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature