PNI as a predictive biomarker: a novel nomogram of immunotherapy efficacy in advanced breast cancer.

ABSTRACT:

Purpose

There has been a persistent upward trend in breast cancer (BC) incidence in recent years. The advancement of immunotherapy has introduced promising therapeutic options. This study focuses on identify potential biomarkers to predict clinical outcomes in advanced BC patients receiving immunotherapy.

Patients and methods

In accordance with the predefined inclusion and exclusion criteria, a cohort of 154 patients were enrolled in this study. Progression-free survival (PFS) and overall survival (OS) were the primary endpoints. The end of follow-up is October 2024. Statistical analyses were performed utilizing IBM SPSS Statistics, version 26.0, and R software, version 4.3.1.

Results

Univariate Cox regression analysis demonstrated a statistically significant associat

SUBMITTER: Li X 

PROVIDER: S-EPMC12395289 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature