Photoinduced Immobilization on Two-Dimensional Nano Borophene Spatially Orients Capture Antibody for Highly Sensitive Biological Interactions.

ABSTRACT: Two-dimensional (2D) nanomaterials are of great interest due to their unique properties and broad biological applications. Among these, borophene, a single-atom-thick boron sheet with a honeycomb structure, exhibits exceptional structural, electronic, and mechanical characteristics, making it a promising candidate for sensing, electronics, and biosensing. In this study, we report on a liquid-phase exfoliation method to synthesize stable borophene nanosheets and introduce a photoinduced immobilization technique to functionalize their surfaces with antibodies. By exploiting borophene's electron-deficient nature, we enable strong covalent bonding with electron-rich thiol groups in antibodies. UV irradiation cleaves antibody disulfide bonds, generating free thiols that form stable boron-sulfur

SUBMITTER: Natarajan S 

PROVIDER: S-EPMC12395291 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature