Recruitment of Aβ into α‑Synuclein Condensates Catalyzes Primary Nucleation of α‑Synuclein Aggregation.

ABSTRACT: The aggregation of amyloid-β (Aβ) and α-synuclein (αSyn) is linked to Alzheimer's and Parkinson's diseases, with growing evidence suggesting possible interactions between Aβ and αSyn in the pathology of these neurodegenerative conditions. In this context, the recent observation that protein aggregation into amyloid fibrils may take place within liquid condensates generated through liquid-liquid phase separation prompts the question of how amyloidogenic proteins interact with each other, and more specifically whether Aβ can influence the overall phase behavior of αSyn or vice versa. To address this question, we investigated the interplay between Aβ40, the most abundant form of Aβ, with αSyn. We found that monomeric Aβ40 is sequestered into αSyn condensates, where it enhances heterogeneous p

SUBMITTER: Morris OM 

PROVIDER: S-EPMC12395293 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature