Excitable dynamics driven by mechanical feedback in biological tissues.

ABSTRACT: Pulsatory activity patterns, driven by mechanochemical feedback, are prevalent in many biological systems. However, the role of cellular mechanics and geometry in the propagation of pulsatory signals remains poorly understood. Here we present a theoretical framework to elucidate the mechanical origin and regulation of pulsatile activity patterns within excitable multicellular tissues. We show that a simple mechanical feedback at the level of individual cells - activation of contractility upon stretch and subsequent inactivation upon turnover of active elements - is sufficient to explain the emergence of quiescent states, long-range wave propagation, and traveling activity pulse at the tissue-level. We find that the transition between a propagating pulse and a wave is driven by the competit

SUBMITTER: Perez-Verdugo F 

PROVIDER: S-EPMC12395394 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature