Chirality-Assisted Self-Assembly of Low-Symmetry Noncovalent Capsules with Quantitative Diastereoisomeric Selection.

ABSTRACT: One of the main aspects in which artificial capsules and cages still differ from their biological counterparts is symmetry─a fundamental trait that gives natural systems exceptional selectivity in molecular recognition. While the symmetry challenge has been recently addressed within metallosupramolecular or covalent systems, the creation of purely noncovalent capsular assemblies with tunable symmetry remains elusive. One exciting avenue toward reducing symmetry is to avail chirality in chiral-sensitive self-assembly, where symmetry is altered upon component binding. Herein, we report new pathways for the self-assembly of purely noncovalent capsules, wherein both the assembly outcome and symmetry can be finely adjusted through the strategic design of hydrogen bonding motifs and chirality. S

SUBMITTER: Markiewicz G 

PROVIDER: S-EPMC12395406 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature