Non-viral HCC miRNA profiling reveals miR-1972 as a potential positive prognostic marker.

ABSTRACT:

Background & aims

Hepatocellular carcinoma (HCC) is the third deadliest cancer worldwide. Its high mortality is primarily attributed to late-stage diagnosis. While mutations in driver genes, such as those encoding β-catenin (CTNNB1), tumor protein p53 (TP53), and telomerase reverse transcriptase promoter (TERTp) are well-documented in the literature, dysregulation of microRNAs (miRNAs), small non-coding RNAs that serve as crucial translational regulators, remains poorly understood.

Methods

We conducted microRNA profiling by microarrays in 45 paired (tumor and non-tumor adjacent tissue) samples from non-viral HCC patients. We performed clinical correlation, ROC analysis and survival analysis of time to recurrence (TTR), disease-free survival (DFS) and overall survival.

Res

SUBMITTER: Mallela VR 

PROVIDER: S-EPMC12395431 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature