Differential expression profiles and bioinformatics analysis of microRNAs in brown adipose tissue dysfunction induced by chronic intermittent hypoxia in obstructive sleep apnea.

ABSTRACT: Obstructive sleep apnea (OSA) is a sleep-related respiratory disorder. Although recent studies have shown that OSA may be an alterable risk factor for metabolic syndrome (MS), the precise mechanism remains unknown. This study was designed with the purpose of identifying differentially expressed microRNAs (DEmiRs) in OSA-induced brown adipose tissue (BAT) injury. In this study, mouse models of chronic intermittent hypoxia (CIH)-related BAT injury were established using APOE mice. The microRNAs (miRNAs) expression profiles of the CIH-caused BAT injury were analyzed by the miRNA sequencing technology. The miRNA-seq data were analyzed using Gene Ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis. An analysis of real-time quantitative PCR (RT-qPCR) confirmed the

SUBMITTER: Ji M 

PROVIDER: S-EPMC12395453 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature