A Chemo-Enzymatic Platform for Furanolide Synthesis and Functional Exploration.

ABSTRACT: Furanolides represent an emerging class of natural products known for their structural diversity and potent bioactivities, including antibiotic, cytotoxic, or algicidal effects. The systematic exploration of their biological activity profiles for the discovery of new hits for drug development thus constitutes a promising endeavor. However, their low natural abundance and the resulting difficulty in obtaining sufficient quantities have limited further in-depth investigations into their biological activity and structure-activity relationships (SARs). Building on our recent discovery of biosynthetic enzymes catalyzing furanolide core-structure assembly, we herein developed a cost-effective, one-pot enzymatic toolbox that enables the fast generation of hundreds of furanolide structural analogs

SUBMITTER: Ji X 

PROVIDER: S-EPMC12395478 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature