An pH-responsive liposome for the targeted treatment of <i>Helicobacter pylori</i>.

ABSTRACT: Objectives With the increase of Helicobacter pylori (H. pylori) drug resistance, it is increasingly difficult to cure H. pylori fundamentally. Frequent and excessive use of antibiotics can lead to disturbances in the intestinal flora and even inflammatory bowel disease, so new drugs are urgently needed. Luteolin (LUT) has been found to have antimicrobial effects, but its water solubility is very low, and the antimicrobial effect is not ideal. To improve the water solubility of LUT and enhance its antibacterial activity, we encapsulated it with liposomes and coated it with chitosan quaternary ammonium salts to increase its targeting and acid responsiveness. Results Compared with LUT, H-L-NPs solubility is significantly improved, and the MIC is reduced by 1024 times, whi

SUBMITTER: Dong H 

PROVIDER: S-EPMC12395506 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature