Effects of Treadmill Exercise on Retinal Vascular Morphology, Function, and Circulating Immune Factors in a Mouse Model of Retinal Degeneration.

ABSTRACT:

Purpose

Exercise is neuroprotective in rodents undergoing retinal degeneration (RD). However, the effects of exercise on retinal vasculature remain unexplored. Here, we investigate whether treadmill exercise influences retinal vascular morphology, function, gene expression, and circulating factors in a light-induced retinal degeneration (LIRD) mouse model.

Methods

Six-week-old female BALB/c mice were assigned to inactive + dim, active + dim, inactive + LIRD, and active + LIRD groups (n = 20 per group). Active mice were treadmill exercised (1 hour/day, 10 meters per minute ]m/min]) for 3 weeks, then, LIRD was induced (5000 lux/4 hours). Inactive mice were placed on a static treadmill. Five days post-LIRD, optical coherence tomography angiography (OCT-A) and functional hyperem

SUBMITTER: Haupt HB 

PROVIDER: S-EPMC12395787 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature