Revisiting the Trans-Ancestry Genetic Correlation of Refractive Error.

ABSTRACT: The prevalence of myopia varies significantly across the globe. This may be a consequence of differences in exposure to lifestyle risk factors or differences in genetic susceptibility across ancestry groups. "Trans-ancestry genetic correlation" quantifies the similarity in genetic predisposition to a trait or disease between different populations. We estimated the trans-ancestry genetic correlation of refractive error across Europeans, South Asians, East Asians, and Africans using recently developed approaches. Two methods were applied: (1) trans-ancestry genetic correlation with unbalanced data resources (TAGC-UDR) and (2) trans-ancestry bivariate genomic-relatedness-based restricted maximum-likelihood (TAB-GREML). TAGC-UDR analyses were carried out for UK Biobank participants of European

SUBMITTER: Clark R 

PROVIDER: S-EPMC12395803 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature