Maternal Faecalibacterium pathobionts and low-fiber diets synergize to impact offspring health: implications for atopic dermatitis.

ABSTRACT:

Background

The incidence of atopic dermatitis (AD) has increased globally in recent decades. A recent study identified enrichment of Faecalibacterium subspecies in young AD patients, implicating these gut bacteria in disease pathogenesis. This was unexpected, as Faecalibacterium is widely recognized as one of the most beneficial bacteria in the human gut.

Results

We tested the bacteria in female mice and observed their effect on the gut microbiome and overall health, which subsequently influenced the health of their offspring. These effects were markedly exacerbated when female mice were fed a low-fiber diet, leading to heightened systemic inflammation, skin damage, and hair loss in their offspring. Offspring of female mice receiving a low-fiber diet without pathobiont admin

SUBMITTER: Lee D 

PROVIDER: S-EPMC12395903 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature