Quantitative magnetization transfer and g-ratio imaging of white matter myelin in early psychotic spectrum disorders.

ABSTRACT: Myelin abnormalities in white matter have been implicated in the pathophysiology of psychotic spectrum disorders (PSD), which are characterized by brain dysconnectivity as a core feature. Among evidence from in vivo MRI studies, diffusion imaging findings have largely supported disrupted white matter integrity in PSD; however, they are not specific to myelin changes. Using a multimodal imaging approach, the current study aimed to further delineate myelin and microstructural changes in the white matter of a young PSD cohort. We utilized quantitative magnetization transfer (qMT) imaging combined with advanced diffusion imaging to estimate specific myelin-related biophysical properties in 51 young adult PSD patients compared with 38 age-matched healthy controls. The macromolecular proton frac

SUBMITTER: Sui YV 

PROVIDER: S-EPMC12395935 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature