Development and Validation of Body Mass Index-Specific Waist Circumference Thresholds in Postmenopausal Women : A Prospective Cohort Study.

ABSTRACT:

Background

A 2020 consensus statement proposed body mass index (BMI)-specific waist circumference (WC) thresholds to improve patient care.

Objective

To determine whether stratifying BMI categories by BMI-specific WC thresholds improves mortality risk prediction.

Design

Prospective cohort study.

Setting

Women's Health Initiative multicenter, population-based U.S. study, with enrollment from 1993 to 1998 and follow-up through 2021.

Participants

139 213 postmenopausal women aged 50 to 79 years were included in a development cohort (n = 67 774) and 2 external validation cohorts. Validation Cohort 1 had high prevalence of overweight or obesity (n = 48 335), and Validation Cohort 2 included diverse, geographically separate centers (n = 23 

SUBMITTER: Aragaki AK 

PROVIDER: S-EPMC12395961 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature