Short- and Long-Term Effect of Multidomain Lifestyle Intervention on Frailty: Post Hoc Analysis of an RCT.

ABSTRACT:

Background

The prevalence of frailty is increasing as the population ages. Lifestyle interventions have shown potential in frailty prevention. Intervention studies have been generally limited by short interventions and follow-ups or by focusing on single-domain approaches. We aimed to investigate whether a 2-year multidomain lifestyle intervention prevents phenotypic pre-frailty or frailty and whether baseline factors predict phenotypic pre-frailty or frailty.

Methods

A total of 1259 participants (aged 60-77 years) in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) were randomized to a multidomain intervention group or to a regular health advice group for 2 years. Frailty was defined by modified Fried phenotype. Pre-frail and

SUBMITTER: Poyhonen J 

PROVIDER: S-EPMC12396167 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature