Polypharmacy's Association With Mortality: Confounding From Underlying Morbidity.

ABSTRACT:

Background

Studies consistently associate use of multiple medications with increased mortality. However, such studies often lack adequate adjustment for confounding, particularly from underlying diseases.

Objective

To illustrate challenges in studying the association between polypharmacy and mortality by examining this relationship in two separate populations.

Methods

A register-based nationwide study utilizing a cohort of all Danish citizens admitted to nursing homes 2015-2021 (n = 95,057) and a community dwelling population cohort aged ≥ 65 years (n = 1,005,963). We examined the 1-year mortality using a Kaplan Meier plot from date of nursing home admission or index date and modeled the association between the number of medications used and death using restricted cub

SUBMITTER: Bjork E 

PROVIDER: S-EPMC12396175 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature