A novel circadian behavior rhythm in arrhythmic <i>Period</i> triple knockout mice revealed by constant light exposure.

ABSTRACT: The current model for autonomous circadian oscillation is based on the transcriptional-translational feedback loops of circadian genes. The deletion of one of the circadian genes and its paralogs leads to arrhythmicity. Period 1/2/3 triple knockout (Per KO) mice exhibit arrhythmic behavior in constant darkness. Molecular oscillations in the primary pacemaker in the suprachiasmatic nucleus (SCN) and peripheral oscillators are blunted in these mice. Here we report that a simple environmental manipulation, constant light exposure (LL), revealed a ∼22 h behavior rhythm in Per KO mice. Ex vivo SCN explanted from behaviorally rhythmic Per KO mice showed disrupted calcium rhythms, suggesting that the rescued rhythm is likely independent of the SCN. Although the

SUBMITTER: Taufique SKT 

PROVIDER: S-EPMC12396279 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature