Bacteriophage immunotherapy with artificial antigen-directed immune labeling against bacterial infection.

ABSTRACT: Bacteriophage therapy has been recognized as a promising anti-infection alternative, while its clinical therapeutic outcomes are compromised due to the development of bacterial resistance, ongoing host immune dysfunction at infection sites, and their failure to adequately revitalize host immunity. Here, we present a strategy for artificial antigen-directed immune labeling of bacteria, capitalizing on residual bacteriophage capsids on bacterial surfaces, which enable immune cells to achieve quicker bacterial recognition and clearance. Specifically, Mn²⁺@Man-phage anchored on bacterial surfaces and provided artificial recognition sites that enabled macrophages to phagocytize via mannose receptors, accompanied by enhanced bactericidal activity triggered by manganese ions in respons

SUBMITTER: Yao M 

PROVIDER: S-EPMC12396327 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature