Two-year outcomes after selective early treatment of patent ductus arteriosus with ibuprofen in preterm babies: follow-up of Baby-OSCAR-a randomised controlled trial.

ABSTRACT:

Background

Children born extremely preterm are at increased risk of developmental problems and respiratory morbidity due to patent ductus arteriosus (PDA). The objective of this study was to evaluate whether early treatment of a PDA ≥1.5 mm with ibuprofen improved neurodevelopmental and respiratory outcomes at 24 months of age, corrected for prematurity.

Methods

Baby-OSCAR was a UK multi-center placebo-controlled masked randomized clinical trial in infants born 23⁺⁰-28⁺⁶ weeks' gestation. The main long-term outcome was survival without moderate or severe neurodevelopmental impairment at 24 months' corrected age, assessed using parent report primarily or classified by blinded end-point review committee where parent-reported data were not available. Other

SUBMITTER: Gupta S 

PROVIDER: S-EPMC12396396 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature