Associations of Genetically Predicted CKD With Urinary Tract Cancer and Lung Cancer: A Mendelian Randomization Analysis.

ABSTRACT:

Rationale & objective

Chronic kidney disease (CKD) is reported to be associated with cancer, especially for urinary tract and lung cancer. However, whether this suggests causality has not been resolved. This study aimed to investigate the causal relation of CKD to overall, urinary tract, and lung cancer.

Study design

Mendelian randomization (MR) analysis.

Setting & participants

Single-nucleotide polymorphism (SNP)-CKD data were obtained from genome-wide association studies of a meta-analysis of CKDGen and UK Biobank. SNP-cancer data from genome-wide association studies of several community-based and cancer-specific consortia were extracted and then meta-analyzed.

Exposures

Impaired kidney function (creatinine-based estimated glomerular filtration rate [eGFRcr] 

SUBMITTER: Luo L 

PROVIDER: S-EPMC12396428 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature