Genome-wide analysis of TMEM38 family revealed functional roles of TMEM38B in fat deposition and its miRNA-mediated regulation in chicken.

ABSTRACT: Transmembrane protein 38 (TMEM38) gene family, including TMEM38A and TMEM38B, is responsible for facilitating trimeric intracellular cation transport across the membrane and regulating key cellular processes, such as muscle contraction and cell differentiation in mammals. However, a genome-wide analysis of the chicken TMEM38 gene family, as well as investigations into their biological roles and post-transcriptional expression regulation in fat deposition have not yet been conducted. In this study, we investigated the genome-wide characteristics of chicken TMEM38 gene family, elucidated the regulatory roles of the TMEM38B gene in both abdominal and intramuscular adipogenesis, and explored its miRNA-mediated expression regulatory mechanisms. We found that chicken TMEM38A and TMEM38B exhibite

SUBMITTER: Li S 

PROVIDER: S-EPMC12396434 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature