Selenium-enriched Lactobacillus coryniformis H8 alleviates LPS-induced jejunal injury in chicks by modulating antioxidant activity, inflammation, selenoprotein genes, and gut microbiota.

ABSTRACT: Intestinal inflammation in chicks remains a prevalent health concern, highlighting the importance of developing effective alternatives to conventional antibiotics. This study aimed to investigate the effect of selenium-enriched Lactobacillus coryniformis H8 (Se-H8) in alleviating lipopolysaccharides (LPS)-induced intestinal inflammation in chicks and the related mechanisms. 252 1-day-old White Leghorn chicks (n = 6 cages/treatment, 6 chicks/cage) were randomly divided into seven groups (Control, LPS, H8, Se-H8, H8-Na2SeO3, Na2SeO3, and ENR). After 14 days of continuous gavage, a 3-day LPS intraperitoneal stress injection was performed. Serum, jejunum, and cecal faeces were collected for analysis of selenium levels, inflammatory factors, antioxidant status, gene expression, and microbial co

SUBMITTER: Xu ZJ 

PROVIDER: S-EPMC12396464 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature