Cryogel scaffolds for localised delivery of lipopolysaccharide in organotypic spinal cord slice cultures: A novel <i>ex vivo</i> model of neuroinflammation.

ABSTRACT: Spinal cord injury (SCI) is a devastating condition for which no curative therapy is currently available. The pathology of SCI is underscored by an inflammatory lesion at the site of injury that exacerbates damage and impedes recovery. Immunomodulation is a promising strategy for SCI repair and thus there is enhanced focus on identifying and testing novel immunotherapeutics. Efficient preclinical models are required for screening new therapies, and ex vivo models can reduce the overall cost and animal numbers required for this process. Organotypic spinal cord slices offer a promising ex vivo platform for modelling spinal cord pathologies as they retain the in vivo tissue architecture with the benefit of a controlled culture environment. Neuroinflammation can be induced

SUBMITTER: Walsh CM 

PROVIDER: S-EPMC12396477 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature