Regulating the cell differentiation trajectory of progenitor cells in adipose tissue fibrosis.

ABSTRACT:

Objective

Adipose fibrosis signifies pathological remodeling of white adipose tissue (WAT) associated with insulin resistance, diabetes, and cardiovascular disease. Matrix Gla protein (MGP) balances bone morphogenetic protein (BMP) and transforming growth factor β (TGFβ) signaling but has an unclear role in WAT.

Methods

To study the role of MGP in WAT, we used mice with global or platelet-derived growth factor receptor α (Pdgfra)-Cre-mediated Mgp deletion in adipose progenitor cells (APCs) together with single cell RNA sequencing (scRNA-seq), characterization on adipose and fibrotic phenotypes, and BMP and TGFβ signaling studies.

Results

Our results showed that Mgp deletion promotes fibrosis and impairs adipogenesis in mice with global or Pdgfra-Cre-mediated Mgp delet

SUBMITTER: Zhang L 

PROVIDER: S-EPMC12396487 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature