A developmental gradient of COUP-TFI expression regulates the relative size of hippocampus dorsal and ventral subregions.

ABSTRACT: The hippocampus is a key brain region for learning and memory that can be divided into multiple compartments, including the dorsal and ventral hippocampi. Each compartment has unique functions, connectivity, and molecular properties. However, the molecular mechanisms underlying the specification of these subregions remain unclear. In this study, we investigated the role of COUP-TFI, a patterning transcription factor expressed in a high-caudal-to-low-rostral gradient in hippocampal progenitors, in establishing the dorsal-ventral axis of the hippocampus in mice. The highest COUP-TFI expression in the hippocampal progenitors was observed in the caudal medial pallium that gives rise to the ventral hippocampus, and the lowest expression was found in rostral medial pallium that develops into the

SUBMITTER: Tseng CS 

PROVIDER: S-EPMC12396750 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature