A dual-ink 3D printing strategy to engineer pre-vascularized bone scaffolds in-vitro.

ABSTRACT: A functional vascular supply is a key component of any large-scale tissue, providing support for the metabolic needs of tissue-remodeling cells. Although well-studied strategies exist to fabricate biomimetic scaffolds for bone regeneration, success rates for regeneration in larger defects can be improved by engineering microvascular capillaries within the scaffolds to enhance oxygen and nutrient supply to the core of the engineered tissue as it grows. Even though the role of calcium and phosphate has been well understood to enhance osteogenesis, it remains unclear whether calcium and phosphate may have a detrimental effect on the vasculogenic and angiogenic potential of endothelial cells cultured on 3D printed bone scaffolds. In this study, we presented a novel dual-ink bioprinting method

SUBMITTER: Twohig C 

PROVIDER: S-EPMC12396787 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature