Continuous Chest Compressions with Asynchronous Ventilation in Asphyxiated Preterm Lambs with Asystole.

ABSTRACT:

Background

Gas exchange and perfusion are impaired during neonatal cardiopulmonary resuscitation. Continuous chest compressions with asynchronous ventilation (CCCaV) improve oxygenation and hemodynamics in term animal models compared to synchronized 3:1 compressions-to-ventilation (C:V). We hypothesized that CCCaV improves gas exchange and hemodynamics in preterm lambs.

Design

Sixteen extremely preterm (124-126 days gestation) lambs were asphyxiated to cardiac arrest by umbilical cord occlusion. Lambs were randomized to 3:1 C:V following the International Liaison Committee on Resuscitation algorithm, or CCCaV (120 compressions and 40 asynchronized ventilations per minute). Epinephrine was given three minutes into resuscitation and repeated every three minutes until return of

SUBMITTER: Giusto E 

PROVIDER: S-EPMC12396845 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature