Expression, Localization, and Processing of Chicken Sperm ADAM32L2 during the Acrosome Reaction: A Possible Function in the Sperm-Egg Interaction.

ABSTRACT: Sperm-egg interactions involve a complex series of molecular events. Among these, the acrosome reaction (AR) is a prerequisite for sperm penetration, facilitating the exposure of multiple acrosomal proteins that enhance sperm binding or penetration of the outer layer of the egg; however, the specific molecules involved in this process vary across species. A disintegrin and metalloproteinase (ADAM) proteins are transmembrane glycoproteins that play a role in sperm-egg interactions, with notable differences among ADAM isoforms. In a previous characterization of the chicken sperm membrane proteome, ADAM32 metallopeptidase domain 32-like 2 (ADAM32L2), a protein structurally homologous to mammalian ADAMs, but absent in mammals, was identified. ADAM32L2 was located in the acrosomal region, under

SUBMITTER: Mohtar MSBM 

PROVIDER: S-EPMC12396854 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature