TNF and type I interferon crosstalk controls the fate and function of plasmacytoid dendritic cells.

ABSTRACT: Plasmacytoid dendritic cells (pDCs) are major producers of type I interferon (IFN-I), an important antiviral cytokine, and activity of these cells must be tightly controlled to prevent harmful inflammation and autoimmunity. Evidence exists that one regulatory mechanism is a fate-switching process from an IFN-I-secreting pDC to a professional antigen-presenting conventional dendritic cell (cDC) that lacks IFN-I-secreting capacity. However, this differentiation process is controversial owing to limitations in tracking the fate of individual cells over time. Here we use single-cell omics and functional experiments to show that activated human pDCs can lose their identity as IFN-I-secreting cells and acquire the transcriptional, epigenetic and functional features of cDCs. This pDC fate-switchi

SUBMITTER: Arroyo Hornero R 

PROVIDER: S-EPMC12396960 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature