Cell-intrinsic platinum response and associated genetic and gene expression signatures in ovarian cancer.

ABSTRACT: Ovarian cancers are still largely treated with platinum-based chemotherapy as the standard of care, yet few biomarkers of clinical response have had an impact on clinical decision making. Previous work has relied on poor models of the most common subtypes of epithelial ovarian cancers and necessitates a careful examination of the most suitable in vitro models. We performed extensive drug dose response assays and gene expression profiling on 36 ovarian cancer cell lines across over seven subtypes. This is the largest quantitative database of quantitative cisplatin and carboplatin response in ovarian cancer cell lines. Our results demonstrate that cell lines largely fall either well above or below the clinical maximally achievable dose (C_max) of each compound. We performed differe

SUBMITTER: Adams KM 

PROVIDER: S-EPMC12396967 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature