Gastroprotective effect of Arabincoside B isolated from Caralluma arabica against ethanol-induced gastric injury via modulating oxidative stress/SP/NK-1R/NF-κB loop.

ABSTRACT: Gastric ulcer is a common gastrointestinal condition. Arabincoside B (AR-B), a pregnane glycoside isolated from the aerial parts of Caralluma arabica, shows multiple pharmacological effects. This study aimed to investigate the gastroprotective therapeutic effects of AR-B in ethanol-induced gastric injury in rats. Rats were divided as follows: Group I (NC): received 1 mL/day of normal saline; Group II (PC): received distilled water then 95% ethanol (1 mL per rat) after 1 h; Group III (FAM): received oral famotidine (20 mg/kg); Groups IV and V (AR-B groups): received 25 and 50 mg/kg of AR-B, respectively. Treatments (FAM or AR-B) were administered 1 h prior to ethanol. The rats were killed after 1 h after ethanol administration. Gross inspections as well as histopathological assessment of st

SUBMITTER: Ali DE 

PROVIDER: S-EPMC12396985 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature