Rationale and design of the Dog Aging Project precision cohort: a multi-omic resource for longitudinal research in geroscience.

ABSTRACT: A significant challenge in multi-omic geroscience research is the collection of high quality, fit-for-purpose biospecimens from a diverse and well-characterized study population with sufficient sample size to detect age-related changes in physiological biomarkers. The Dog Aging Project designed the precision cohort to study the mechanisms underlying age-related change in the metabolome, microbiome, and epigenome in companion dogs, an emerging model system for translational geroscience research. One thousand dog-owner pairs were recruited into cohort strata based on life stage, sex, size, and geography. We designed and built a novel implementation of the REDCap electronic data capture system to manage study participants, logistics, and biospecimen and survey data collection in a secure onli

SUBMITTER: Prescott J 

PROVIDER: S-EPMC12397037 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature