Preserved brain youthfulness: longitudinal evidence of slower brain aging in superagers.

ABSTRACT:

Background

Superagers, older adults with exceptional cognitive abilities, show preserved brain structure compared to typical older adults. We investigated whether superagers have biologically younger brains based on their structural integrity.

Methods

A cohort of 153 older adults (aged 61-93) was recruited, with 63 classified as superagers based on superior episodic memory and 90 as typical older adults, of whom 64 were followed up after two years. A deep learning model for brain age prediction, trained on 899 diverse-aged adults (aged 31-100), was adapted to the older adult cohort via transfer learning. Brain age gap (BAG), a metric based on brain structural patterns, defined as the difference between predicted and chronological age, and its annual rate of change were calcu

SUBMITTER: Park CH 

PROVIDER: S-EPMC12397054 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature