Higher pre-diagnostic serum syndecan-4 levels are associated with increased breast cancer risk: a case-cohort study.

ABSTRACT:

Purpose

Syndecans are transmembrane proteins involved in inflammation and signaling pathways. Their potential role as pre-diagnostic biomarkers for breast cancer risk remains unexplored. This study aimed to investigate whether pre-diagnostic serum syndecan levels are associated with breast cancer risk in a population-based cohort.

Methods

We conducted a case-cohort study nested within the Tromsø Study (Norway), including women who participated in the fifth survey (2001). Women with incident breast cancer (cases, n = 158) through 2022 were identified, with a random sub-cohort of 708 women. Serum levels of syndecan-1 (SDC1) and syndecan-4 (SDC4) were measured using ELISA on frozen serum samples obtained in 2001. All participants were stratified into quartiles (Q1-Q4) based on

SUBMITTER: Gabrielsen E 

PROVIDER: S-EPMC12397127 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature