Fast 4D-PET parametric imaging computation at the whole field of view level: Reliability under simulated conditions of PET KinetiX, a dedicated software solution.

ABSTRACT:

Purpose

The reliability of a new academic software, PET KinetiX, designed for fast parametric 4D-PET imaging computation, is assessed under simulated conditions.

Methods

4D-PET data were simulated using the XCAT digital phantom and realistic time-activity curves (ground truth). Four hundred analytical simulations were reconstructed using CASToR, an open-source software for tomographic reconstruction, replicating the clinical characteristics of two available PET systems with short and long axial fields of view (SAFOV and LAFOV). A total of 2,800 Patlak and 2TCM kinetic parametric maps of ¹⁸F-FDG were generated using PET KinetiX. The mean biases and standard deviations of the kinetic parametric maps were computed for each tissue label and compared to the biases of u

SUBMITTER: Faure S 

PROVIDER: S-EPMC12397132 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature