Two-step ultrasonic cavitation controlled delivery of brain exogenous nucleic acids for ischemic stroke using acoustic-cationic-polymeric-nanodroplets.

ABSTRACT: Inefficient and low-precision delivery of exogenous nucleic acids (ENA) severely limits gene therapy on ischemic stroke (IS). Two problems need to be urgently addressed to improve the efficacy of gene therapy; first, the blood brain barrier (BBB) should be open to promote the accumulation of ENA or genetic material carriers in the ischemic brain parenchyma, and second, the efficient delivery of ENA into the ischemic cells. Previous studies applied ultrasonic cavitation either for opening BBB or for inducing sonoporation to deliver genetic materials into cells. However, the effectiveness of the two-step ultrasonic cavitation to deliver ENA in the brain remains unclear, let alone the genetic materials to be controllably delivered into the ischemic brain parenchyma of the IS. This study syste

SUBMITTER: Dong W 

PROVIDER: S-EPMC12397173 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature