Intrinsic brain functional connectivity mediates the relationship between psychological resilience and cognitive decline in ageing.

ABSTRACT: Ageing individuals often experience cognitive decline and intrinsic functional connectivity (FC) changes. Psychological resilience, a personality trait that reflects the capacity to adapt and cope with age-related challenges, plays a key role in mitigating cognitive decline. In this study involving 101 older adults, we investigated how psychological resilience influences cognitive decline measured by processing speed. Particularly, we obtained resting-state functional magnetic resonance imaging (fMRI) to assess how intrinsic FC, represented by degree centrality, modulates the relationship between resilience and processing speed. Our results indicated while psychological resilience positively predicted processing speed, this relationship was mainly driven by education. Additionally, the deg

SUBMITTER: Chen M 

PROVIDER: S-EPMC12397464 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature