The CROCO (CROhn's Disease COhort Study) - study design and protocol.

ABSTRACT:

Background

Crohn's disease (CD) is a chronic, relapsing and remitting inflammatory bowel disease that can be associated with significant bowel damage and disability. The Lémann Index (LI) is a validated tool for measuring cumulative bowel damage in CD patients through a comprehensive assessment of stricturing, penetrating and surgical lesions. However, prospective studies evaluating bowel damage progression in recently diagnosed CD patients remain limited.

Objectives

To characterise the absolute and longitudinal variations in bowel damage progression, as measured by the LI, in a cohort of recently diagnosed CD patients, and to assess its association with relevant disease features, including disease phenotype, treatment strategies, biomarkers and disability.

Design

Stu

SUBMITTER: Reves J 

PROVIDER: S-EPMC12397584 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature