Association of decreased thalamic neurotransmitter level with sensorimotor tract damage in patients with relapsing-remitting multiple sclerosis.

ABSTRACT:

Background

Thalamic microstructural damage and neurotransmission dysfunction are present in patients with multiple sclerosis (MS). The aim of this study was to investigate the relationship of altered γ-aminobutyric acid (GABA) and glutamate + glutamine (Glx) levels in the thalamus with the white-matter (WM) microstructural damage of the sensorimotor tract in patients with relapsing-remitting MS (RRMS).

Methods

In this cross-sectional study, 50 patients with RRMS and 43 healthy controls (HCs) were scanned using Mescher-Garwood point resolved spectroscopy (MEGA-PRESS) to quantify the GABA+ and Glx level of the thalamus. Metrics derived from diffusion tensor imaging (DTI) were calculated to reflect the degree of WM microstructural damage of the sensorimotor tract. The correlati

SUBMITTER: Xie Y 

PROVIDER: S-EPMC12397645 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature