Association analysis of intratumoral metabolic heterogeneity assessed by the hottest lesion based on ¹⁸F-FDG PET/CT with immunochemotherapy response in diffuse large B-cell lymphoma.

ABSTRACT:

Background

Intratumoral metabolic heterogeneity (MH) assessed by 18-fluorine fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG PET/CT) has been recognized as a potential marker for chemotherapy resistance in solid tumors. However, research on MH in diffuse large B-cell lymphoma (DLBCL) is limited, and its specific relationship with the response to immunochemotherapy (IC) remains unclear. The objective of this study was to investigate optimal approaches for assessing intratumoral MH, and to analyze the association between PET/CT-based MH and end of treatment (EOT) response to IC in DLBCL.

Methods

This study retrospectively enrolled 304 newly diagnosed patients with DLBCL who underwent baseline ¹⁸F-FDG PET/CT scanning. Intratumo

SUBMITTER: Xin W 

PROVIDER: S-EPMC12397664 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature